Pemetrexed for previously treated patients with metastatic gastric cancer: a prospective phase II study.

ABSTRACT:

Background

Gastric cancer is one of the leading causes of cancer-related death worldwide. There were debates on the value of the second-line and beyond chemotherapy by the time we designed this trial. So we designed this phase II trial to assess the efficacy and safety of pemetrexed in patients with pretreated metastatic gastric cancer.

Methods

Thirty-four patients with pretreated metastatic gastric cancer were enroled in the study. Patients received pemetrexed 500 mg m(-2) every 21 days until the presence of progressive disease (PD) or unacceptable toxicity.

Results

A total of 34 patients were enroled in the study; 34 were eligible for toxicity and 30 for response. The response rate was 13.3%, 13.3% patients achieved a partial response, 50.0% achieved stable disease

SUBMITTER: Zhang DS 

PROVIDER: S-EPMC4453460 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature