Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome.

ABSTRACT:

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Treatment of vulvovaginal candidiasis (VVC), caused most frequently by Candida albicans, represents a significant unmet clinical need. C. albicans, as both a commensal and a pathogenic organism, has a complex and poorly understood interaction with the vaginal environment. Understanding the complex nature of this relationship is necessary for the development of desperately needed therapies to treat symptomatic infection. Using transcriptome sequencing (RNA-seq), we characterized the early murine vaginal and fungal transcriptomes of the organism during VVC. Network analysis of host genes that were differentially expressed between infected and naive mice predicted the activation or repression of several signaling pathways that have not been previously associated with VVC, i

SUBMITTER: Bruno VM 

PROVIDER: S-EPMC4453569 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature