Identification of novel vascular targets in lung cancer.

ABSTRACT:

Background

Lung cancer remains the leading cause of cancer-related death, largely owing to the lack of effective treatments. A tumour vascular targeting strategy presents an attractive alternative; however, the molecular signature of the vasculature in lung cancer is poorly explored. This work aimed to identify novel tumour vascular targets in lung cancer.

Methods

Enzymatic digestion of fresh tissue followed by endothelial capture with Ulex lectin-coated magnetic beads was used to isolate the endothelium from fresh tumour specimens of lung cancer patients. Endothelial isolates from the healthy and tumour lung tissue were subjected to whole human genome expression profiling using microarray technology.

Results

Bioinformatics analysis identified tumour endothelial expre

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC4453649 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature