Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage.

ABSTRACT:

Background

The mechanisms by which stress hormones impact triple-negative breast cancer (TNBC) etiology and treatment are unclear. We have previously shown that stress hormones, cortisol, and catecholamines induce rapid DNA damage and impact DNA repair in NIH 3T3 fibroblasts. This study investigates whether stress hormones increase DNA damage in breast cancer cells and if this impacts drug efficacy.

Methods

We first screened a panel of 39 breast cancer cell lines for expression of adrenergic and glucocorticoid receptors and examined if stress hormones induce DNA damage and alter cell cycle regulation in vitro. A TNBC xenograft model was used to assess the impact of restraint stress on tumour growth and chemosensitivity to paclitaxel.

Results

We found that stress hormo

SUBMITTER: Reeder A 

PROVIDER: S-EPMC4453678 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature