Syntheses of arnottin I and arnottin II.

ABSTRACT: Short total syntheses of arnottin I and II were accomplished in 5 and 6 steps, respectively. A sesamol-benzyne cycloaddition with a 3-furyl-benzoate followed by regiospecific lactonization provided rapid, large-scale access to the core of arnottin I. Saponification of arnottin I and hypervalent iodide mediated spirocyclization provided an efficient and direct preparation of racemic arnottin II.

SUBMITTER: Moschitto MJ 

PROVIDER: S-EPMC4453770 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature