Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.

ABSTRACT:

Background

Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension.

Methods

A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to evaluate for an association between genotypes and hypertension. GWAS was conducted in those who had experienced systolic blood pressure (SBP) >160 mm Hg during therapy using binary analysis and a cumulative dose model for the total exposure of bevacizumab. Common toxicity criteria (CTC) grade 3-5 hypertension was also assessed. Candidate SNP validation was performed in the randomised phase III trial, ECOG-2100.

Results

When using the phenotype of SBP>160 mm 

SUBMITTER: Schneider BP 

PROVIDER: S-EPMC4453857 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature