Draft genomes of Shigella strains used by the STOPENTERICS consortium.

ABSTRACT:

Background

Despite a significant global burden of disease, there is still no vaccine against shigellosis widely available. One aim of the European Union funded STOPENTERICS consortium is to develop vaccine candidates against Shigella. Given the importance of translational vaccine coverage, here we aimed to characterise the Shigella strains being used by the consortium by whole genome sequencing, and report on the stability of strains cultured in different laboratories or through serial passage.

Methods

We sequenced, de novo assembled and annotated 20 Shigella strains being used by the consortium. These comprised 16 different isolates belonging to 7 serotypes, and 4 derivative strains. Derivative strains from common isolates were manipulated in different laboratories or had u

SUBMITTER: Rossi O 

PROVIDER: S-EPMC4454270 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature