Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass.

ABSTRACT:

Aims

Genetic variation in the fatty acid translocase (CD36) gene has been shown in animal models to affect several risk factors for the development of left-ventricular hypertrophy, but this phenotype has not, thus far, been investigated in humans. We examined the relationship between common genetic polymorphisms in the CD36 gene and left-ventricular mass.

Methods and results

We studied a cohort of 255 families comprising 1425 individuals ascertained via a hypertensive proband. Seven single-nucleotide polymorphisms which together tagged common genetic variation in the CD36 gene were genotyped using a SEQUENOM MALDI-TOF instrument. There was evidence of association between the rs1761663 polymorphism in intron 1 of the CD36 gene and left-ventricular mass determined either by ec

SUBMITTER: Hall D 

PROVIDER: S-EPMC4454277 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature