Intravenous Mycobacterium Bovis Bacillus Calmette-Guerin Ameliorates Nonalcoholic Fatty Liver Disease in Obese, Diabetic ob/ob Mice.

ABSTRACT: Inflammation and immune response profoundly influence metabolic syndrome and fatty acid metabolism. To analyze influence of systemic inflammatory response to metabolic syndrome, we inoculated an attenuated vaccine strain of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) into leptin-deficient ob/ob mice. BCG administration significantly decreased epididymal white adipose tissue weight, serum insulin levels, and a homeostasis model assessment of insulin resistance. Serum high molecular weight (HMW) adiponectin level and HMW/total adiponectin ratio of the BCG treated mice were significantly higher than those of control mice. Hepatic triglyceride accumulation and macrovesicular steatosis were markedly alleviated, and the enzymatic activities and mRNA levels of lipogenic-related genes in li

SUBMITTER: Inafuku M 

PROVIDER: S-EPMC4454685 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature