LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal.

ABSTRACT:

Context

Aldosterone synthesis and cellularity in the human adrenal zona glomerulosa (ZG) is sparse and patchy, presumably due to salt excess. The frequency of somatic mutations causing aldosterone-producing adenomas (APAs) may be a consequence of protection from cell loss by constitutive aldosterone production.

Objective

The objective of the study was to delineate a process in human ZG, which may regulate both aldosterone production and cell turnover.

Design

This study included a comparison of 20 pairs of ZG and zona fasciculata transcriptomes from adrenals adjacent to an APA (n = 13) or a pheochromocytoma (n = 7).

Interventions

Interventions included an overexpression of the top ZG gene (LGR5) or stimulation by its ligand (R-spondin-3).

Main outcome measure

SUBMITTER: Shaikh LH 

PROVIDER: S-EPMC4454794 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature