Diabetes and congenital heart defects: a systematic review, meta-analysis, and modeling project.

ABSTRACT:

Context

Maternal pregestational diabetes (PGDM) is a risk factor for development of congenital heart defects (CHDs). Glycemic control before pregnancy reduces the risk of CHDs. A meta-analysis was used to estimate summary ORs and mathematical modeling was used to estimate population attributable fractions (PAFs) and the annual number of CHDs in the U.S. potentially preventable by establishing glycemic control before pregnancy.

Evidence acquisition

A systematic search of the literature through December 2012 was conducted in 2012 and 2013. Case-control or cohort studies were included. Data were abstracted from 12 studies for a meta-analysis of all CHDs.

Evidence synthesis

Summary estimates of the association between PGDM and CHDs and 95% credible intervals (95% CrIs) we

SUBMITTER: Simeone RM 

PROVIDER: S-EPMC4455032 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature