Change in Multiple Filtration Markers and Subsequent Risk of Cardiovascular Disease and Mortality.

ABSTRACT:

Background and objectives

Kidney disease progression, assessed by change in eGFR on the basis of creatinine, is an independent risk factor for cardiovascular disease and death. This study aimed to evaluate whether changes in multiple filtration markers, individually and combined, were associated with cardiovascular disease and death.

Design, setting, participants, & measurements

Creatinine, cystatin C, and β2-microglobulin were measured among 9716 Atherosclerosis Risk in Communities Study participants in 1990-1992 and 1996-1998. Percentage change in three filtration markers (eGFR on the basis of creatinine, eGFR on the basis of cystatin C, and 1/β2-microglobulin) individually and the average of percentage change across all three filtration markers were calculated. Cardiovasc

SUBMITTER: Rebholz CM 

PROVIDER: S-EPMC4455217 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature