Unraveling the Mechanism for the Viability Deficiency of Shewanella oneidensis oxyR Null Mutant.

ABSTRACT:

Unlabelled

Oxidative stresses triggered by reactive oxygen species (ROS) that damage various cellular components are unavoidable for virtually all living organisms. In defense, microorganisms have evolved sophisticated mechanisms to sense, respond to, and battle against ROS. Shewanella oneidensis, an important research model for applied and environmental microbes, employs OxyR to mediate the response to H2O2 by derepressing the production of the major H2O2 scavenger KatB as a major means toward these goals. Surprisingly, despite enhanced H2O2 degradation, the oxyR mutant carries a viability deficiency phenotype (plating defect), which can be suppressed by the addition of exogenous iron species. Experiments showed that the defect was not due to iron starvation. Rather, multiple line

SUBMITTER: Shi M 

PROVIDER: S-EPMC4455265 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature