Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.

ABSTRACT:

Purpose

To test if MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe that is sensitive and specific for the proinflammatory and oxidative enzyme myeloperoxidase (MPO), which is secreted by certain inflammatory cells, is more sensitive than diethylenetriaminepentaacetic acid (DTPA)-Gd in revealing early subclinical and chronic disease activity in the brain in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis.

Materials and methods

The protocol for animal experiments was approved by the institutional animal care committee. A total of 61 female SJL mice were induced with EAE. Mice underwent MPO-Gd- or DTPA-Gd-enhanced MR imaging on days 6, 8, and 10 after induction, before clinical disease develops, and during chronic disease at

SUBMITTER: Pulli B 

PROVIDER: S-EPMC4455671 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature