Elevated sodium and dehydration stimulate inflammatory signaling in endothelial cells and promote atherosclerosis.

ABSTRACT: Cardiovascular diseases (CVDs) are a leading health problem worldwide. Epidemiologic studies link high salt intake and conditions predisposing to dehydration such as low water intake, diabetes and old age to increased risk of CVD. Previously, we demonstrated that elevation of extracellular sodium, which is a common consequence of these conditions, stimulates production by endothelial cells of clotting initiator, von Willebrand Factor, increases its level in blood and promotes thrombogenesis. In present study, by PCR array, using human umbilical vein endothelial cells (HUVECs), we analyzed the effect of high NaCl on 84 genes related to endothelial cell biology. The analysis showed that the affected genes regulate many aspects of endothelial cell biology including cell adhesion, proliferatio

SUBMITTER: Dmitrieva NI 

PROVIDER: S-EPMC4456159 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature