Integrative approach to analyze biodiversity and anti-inflammatory bioactivity of Wedelia medicinal plants.

ABSTRACT: For the development of "medical foods" and/or botanical drugs as defined USA FDA, clear and systemic characterizations of the taxonomy, index phytochemical components, and the functional or medicinal bioactivities of the reputed or candidate medicinal plant are needed. In this study, we used an integrative approach, including macroscopic and microscopic examination, marker gene analysis, and chemical fingerprinting, to authenticate and validate various species/varieties of Wedelia, a reputed medicinal plant that grows naturally and commonly used in Asian countries. The anti-inflammatory bioactivities of Wedelia extracts were then evaluated in a DSS-induced murine colitis model. Different species/varieties of Wedelia exhibited distinguishable morphology and histological structures. Analysis

SUBMITTER: Lin WC 

PROVIDER: S-EPMC4456162 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature