Paracrine action of mesenchymal stem cells revealed by single cell gene profiling in infarcted murine hearts.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) have been recently demonstrated as a promising stem cell type to rescue damaged myocardium after acute infarction. One of the most important mechanisms underlying their therapeutic effects is the secretion of paracrine factors. However, the expression profile of paracrine factors of MSCs in infarcted hearts, especially at single cell level, is poorly defined.

Methods and results

We aimed to depict the transcriptional profile of paracrine factors secreted by MSCs in vivo, with particular interest in the comparison between normal and infarcted hearts. Bone marrow mesenchymal stem cells were isolated and injected into mice hearts immediately after infarction surgery. Bioluminescence imaging (BLI) indicated a proportion of cells still ali

SUBMITTER: Yao Y 

PROVIDER: S-EPMC4456391 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature