Endothelial function and insulin sensitivity during acute non-esterified fatty acid elevation: Effects of fat composition and gender.

ABSTRACT:

Background and aims

We have reported that adverse effects on flow-mediated dilation of an acute elevation of non-esterified fatty acids rich in saturated fat (SFA) are reversed following addition of long-chain (LC) n-3 polyunsaturated fatty acids (PUFA), and hypothesised that these effects may be mediated through alterations in insulin signalling pathways. In a subgroup, we explored the effects of raised NEFA enriched with SFA, with or without LC n-3 PUFA, on whole body insulin sensitivity (SI) and responsiveness of the endothelium to insulin infusion.

Methods and results

Thirty adults (mean age 27.8 y, BMI 23.2 kg/m(2)) consumed oral fat loads on separate occasions with continuous heparin infusion to elevate NEFA between 60 and 390 min. For the final 150 min, a hyperinsulin

SUBMITTER: Newens KJ 

PROVIDER: S-EPMC4456421 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature