A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.

ABSTRACT: Influenza A virus causes considerable morbidity and mortality largely because of a lack of effective antiviral drugs. Viral neuraminidase inhibitors, which inhibit viral release from the infected cell, are currently the only approved drugs for influenza, but have recently been shown to be less effective than previously thought. Growing resistance to therapies that target viral proteins has led to increased urgency in the search for novel anti-influenza compounds. However, discovery and development of new drugs have been restricted because of differences in susceptibility to influenza between animal models and humans and a lack of translation between cell culture and in vivo measures of efficacy. To circumvent these limitations, we developed an experimental approach based on ex vivo infecti

SUBMITTER: Nicholas B 

PROVIDER: S-EPMC4456633 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature