GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.

ABSTRACT: GTPase of the immunity-associated protein (GIMAP) family members are differentially regulated during human Th cell differentiation and have been previously connected to immune-mediated disorders in animal studies. GIMAP4 is believed to contribute to the Th cell subtype-driven immunological balance via its role in T cell survival. GIMAP5 has a key role in BB-DR rat and NOD mouse lymphopenia. To elucidate GIMAP4 and GIMAP5 function and role in human immunity, we conducted a study combining genetic association in different immunological diseases and complementing functional analyses. Single nucleotide polymorphisms tagging the GIMAP haplotype variation were genotyped in Finnish type 1 diabetes (T1D) families and in a prospective Swedish asthma and allergic sensitization birth cohort. Initiall

SUBMITTER: Heinonen MT 

PROVIDER: S-EPMC4456634 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature