Neonatal exposure to pneumococcal phosphorylcholine modulates the development of house dust mite allergy during adult life.

ABSTRACT: Currently, ∼20% of the global population suffers from an allergic disorder. Allergies and asthma occur at higher rates in developed and industrialized countries. It is clear that many human atopic diseases are initiated neonatally and herald more severe IgE-mediated disorders, including allergic asthma, which is driven by the priming of Th2 effector T cells. The hygiene hypothesis attempts to link the increased excessively sanitary conditions early in life to a default Th2 response and increasing allergic phenomena. Despite the substantial involvement of IgE Abs in such conditions, little attention has been paid to the effects of early microbial exposure on the B cell repertoire prior to the initiation of these diseases. In this study, we use Ab-binding assays to demonstrate that Streptoco

SUBMITTER: Patel PS 

PROVIDER: S-EPMC4456637 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature