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In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography.

ABSTRACT: The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches for in vivo cochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24?hours as seen at 3.5?hours after injection allowing for repeated quantification in the living mouse eyes.

SUBMITTER: Wang J 

PROVIDER: S-EPMC4457137 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography.

Wang Jianhua J   Aljohani Ayman A   Carreon Teresia T   Gregori Giovanni G   Bhattacharya Sanjoy K SK  

Scientific reports 20150605

The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches for in vivo cochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24 hours as seen at 3.5 hours after injection allowing for repeated q  ...[more]

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