Application of Comparative Transcriptional Genomics to Identify Molecular Targets for Pediatric IBD.

ABSTRACT: Experimental models of colitis in mice have been used extensively for analyzing the molecular events that occur during inflammatory bowel disease (IBD) development. However, it is uncertain to what extent the experimental models reproduce features of human IBD. This is largely due to the lack of precise methods for direct and comprehensive comparison of mouse and human inflamed colon tissue at the molecular level. Here, we use global gene expression patterns of two sets of pediatric IBD and two mouse models of colitis to obtain a direct comparison of the genome signatures of mouse and human IBD. By comparing the two sets of pediatric IBD microarray data, we found 83 genes were differentially expressed in a similar manner between pediatric Crohn's disease and ulcerative colitis. Up-regulati

SUBMITTER: Fang K 

PROVIDER: S-EPMC4457140 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature