Gene Expression Associated with Early and Late Chronotypes in Drosophila melanogaster.

ABSTRACT: The circadian clock provides the temporal framework for rhythmic behavioral and metabolic functions. In the modern era of industrialization, work, and social pressures, clock function is jeopardized, and can result in adverse and chronic effects on health. Understanding circadian clock function, particularly individual variation in diurnal phase preference (chronotype), and the molecular mechanisms underlying such chronotypes may lead to interventions that could abrogate clock dysfunction and improve human (and animal) health and welfare. Our preliminary studies suggested that fruit-flies, like humans, can be classified as early rising "larks" or late rising "owls," providing a convenient model system for these types of studies. We have identified strains of flies showing increased prefere

SUBMITTER: Pegoraro M 

PROVIDER: S-EPMC4457141 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature