Bayesian multivariate augmented Beta rectangular regression models for patient-reported outcomes and survival data.

ABSTRACT: Many longitudinal studies (e.g. observational studies and randomized clinical trials) have collected multiple rating scales at each visit in the form of patient-reported outcomes (PROs) in the close unit interval [0 ,1]. We propose a joint modeling framework to address the issues from the following data features: (1) multiple correlated PROs; (2) the presence of the boundary values of zeros and ones; (3) extreme outliers and heavy tails; (4) the PRO-dependent terminal events such as death and dropout. Our modeling framework consists of a multivariate augmented mixed-effects sub-model based on Beta rectangular distributions for the multiple longitudinal outcomes and a Cox model for the terminal events. The simulation studies suggest that in the presence of outliers, heavy tails, and depende

SUBMITTER: Wang J 

PROVIDER: S-EPMC4457342 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature