Systems medicine: evolution of systems biology from bench to bedside.

ABSTRACT: High-throughput experimental techniques for generating genomes, transcriptomes, proteomes, metabolomes, and interactomes have provided unprecedented opportunities to interrogate biological systems and human diseases on a global level. Systems biology integrates the mass of heterogeneous high-throughput data and predictive computational modeling to understand biological functions as system-level properties. Most human diseases are biological states caused by multiple components of perturbed pathways and regulatory networks rather than individual failing components. Systems biology not only facilitates basic biological research but also provides new avenues through which to understand human diseases, identify diagnostic biomarkers, and develop disease treatments. At the same time, systems bi

SUBMITTER: Wang RS 

PROVIDER: S-EPMC4457580 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature