Ontology highlight
ABSTRACT:
SUBMITTER: Ding J
PROVIDER: S-EPMC4458159 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Cell stem cell 20150430 6
Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage-specific transcription factors driving expression of genes that define cell identity. In embryonic stem cells (ESCs), SEs are highly enriched for the core pluripotency factors Oct4, Sox2, and Nanog. In this study, we sought to dissect the molecular control mechanism of SE activity in pluripotency and reprogramming. Starting from a protein interaction network surrounding Sox2, we identif ...[more]