A review of pharmacogenetic studies of substance-related disorders.

ABSTRACT:

Background

Substance-related disorders (SRDs) are a major cause of morbidity and mortality worldwide. Family, twin, and adoption studies have demonstrated the substantial heritability of SRDs. To determine the impact of genetic variation on risk for SRD and the response to treatment, researchers have conducted a number of secondary data analyses and quasi-experimental studies that target one or more candidate gene variants.

Methods

This review examines studies in which candidate polymorphisms were examined as mediator variables to identify pharmacogenetic effects on subjective responses to drug administration or cues or outcomes of medication trials for SRDs. Efforts to use a meta-analytic approach to quantify these effects are premature because the number of available studi

SUBMITTER: Jones JD 

PROVIDER: S-EPMC4458176 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature