Ontology highlight
ABSTRACT:
SUBMITTER: Omura T
PROVIDER: S-EPMC4458182 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Neuron 20150521 5
Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on CNS myelin than the other eight strains tested, especially when pre-injured. Injury-primed CAST/Ei neurons also regenerate markedly in the spinal cord and optic nerve more than those from C57BL/6 mice and show greater sproutin ...[more]