Is the association between depressive symptoms and glucose metabolism bidirectional? Evidence from the English Longitudinal Study of Ageing.

ABSTRACT:

Objective

To examine whether the prospective association between depressive symptoms and glucose metabolism is bidirectional.

Methods

We used a national sample of 4238 community-dwelling individuals 50 years or older from the English Longitudinal Study of Ageing. Participants were categorized into normoglycemic, impaired glucose metabolism (IGM), and undiagnosed and diagnosed diabetes using glycated hemoglobin and self-reported doctor diagnosis. Subthreshold and elevated depressive symptoms were defined by a score between 2 and 3 and 4 or higher, respectively, on the eight-item Center for Epidemiological Studies-Depression scale.

Results

In the age-adjusted model, categories of depressive symptoms were associated with incident undiagnosed (odds ratio [OR] = 1.54 [95%

SUBMITTER: Demakakos P 

PROVIDER: S-EPMC4458700 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature