Low G preconditioning reduces liver injury induced by high +Gz exposure in rats.

ABSTRACT:

Aim

To investigate the effect of repeated lower +Gz exposure on liver injury induced by high +Gz exposure in rats.

Methods

Sixty male Wister rats were randomly divided into a blank control group, a low G preconditioning group (LG) (exposed to +4 Gz/5 min per day for 3 d before +10 Gz/5 min exposure), and a +10 Gz/5 min group (10G) (n = 20 in each group). Blood specimens and liver tissue were harvested at 0 h and 6 h after +10 Gz/5 min exposure. Liver function was analyzed by measuring serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, and liver injury was further assessed by histopathological observation. Malondialdehyde (MDA), superoxide dismutase (SOD) and Na(+)-K(+)-ATPase were determined in hepatic tissue.

Results

The group LG had lower

SUBMITTER: Shi B 

PROVIDER: S-EPMC4458764 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature