Statins, cognition, and dementia—systematic review and methodological commentary.

ABSTRACT: Firm conclusions about whether mid-life or long-term statin use has an impact on cognitive decline and dementia remain elusive. Here, our objective was to systematically review, synthesize and critique the epidemiological literature that examines the relationship between statin use and cognition, so as to assess the current state of knowledge, identify gaps in our understanding, and make recommendations for future research. We summarize the findings of randomized controlled trials (RCTs) and observational studies, grouped according to study design. We discuss the methods for each, and consider likely sources of bias, such as reverse causation and confounding. Although observational studies that considered statin use at or near the time of dementia diagnosis suggest a protective effect of s

SUBMITTER: Power MC 

PROVIDER: S-EPMC4458855 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature