Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials.

ABSTRACT:

Background

Greater understanding of factors associated with the high placebo-response rates noted in recent neuropathic pain trials may improve trial design. This study investigated placebo response and its predictors in pregabalin trials in patients with diabetic peripheral neuropathy (DPN) or postherpetic neuralgia.

Patients and methods

Individual patient data from 16 randomized, placebo-controlled, double-blind trials of pregabalin in 3,053 patients with DPN and 1,460 patients with postherpetic neuralgia were pooled (by condition and all together) in order to investigate the placebo response and its predictors. Univariate and multivariate analyses were performed across all 16 trials to identify predictors of change in pain score in patients. Trials with a >2-point mean re

SUBMITTER: Freeman R 

PROVIDER: S-EPMC4459620 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature