Synthesis and structure-activity relationships of novel cationic lipids with anti-inflammatory and antimicrobial activities.

ABSTRACT: Certain membrane-active cationic steroids are known to also possess both anti-inflammatory and antimicrobial properties. This combined functionality is particularly relevant for potential therapies of infections associated with elevated tissue damage, for example, cystic fibrosis airway disease, a condition characterized by chronic bacterial infections and ongoing inflammation. In this study, six novel cationic glucocorticoids were synthesized using beclomethasone, budesonide, and flumethasone. Products were either monosubstituted or disubstituted, containing one or two steroidal groups, respectively. In vitro evaluation of biological activities demonstrated dual anti-inflammatory and antimicrobial properties with limited cytotoxicity for all synthesized compounds. Budesonide-derived compo

SUBMITTER: Myint M 

PROVIDER: S-EPMC4459899 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature