Ontology highlight
ABSTRACT:
SUBMITTER: Grieco AJ
PROVIDER: S-EPMC4459969 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Grieco Amanda J AJ Billett Henny H HH Green Nancy S NS Driscoll M Catherine MC Bouhassira Eric E EE
PloS one 20150608 6
The molecular mechanisms governing γ-globin expression in a subset of fetal hemoglobin (α2γ2: HbF) expressing red blood cells (F-cells) and the mechanisms underlying the variability of response to hydroxyurea induced γ-globin expression in the treatment of sickle cell disease are not completely understood. Here we analyzed intra-person clonal populations of basophilic erythroblasts (baso-Es) derived from bone marrow common myeloid progenitors in serum free cultures and report the level of fetal ...[more]