Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo.

ABSTRACT: Homeostatic regulation has been shown to restore cortical activity in vivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. The

SUBMITTER: Barnes SJ 

PROVIDER: S-EPMC4460189 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature