Non-monotonic reorganization of brain networks with Alzheimer's disease progression.

ABSTRACT:

Background

Identification of stage-specific changes in brain network of patients with Alzheimer's disease (AD) is critical for rationally designed therapeutics that delays the progression of the disease. However, pathological neural processes and their resulting changes in brain network topology with disease progression are not clearly known.

Methods

The current study was designed to investigate the alterations in network topology of resting state fMRI among patients in three different clinical dementia rating (CDR) groups (i.e., CDR = 0.5, 1, 2) and amnestic mild cognitive impairment (aMCI) and age-matched healthy subject groups. We constructed density networks from these 5 groups and analyzed their network properties using graph theoretical measures.

Results

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SUBMITTER: Kim H 

PROVIDER: S-EPMC4460428 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature