Changes in task-based effective connectivity in language networks following rehabilitation in post-stroke patients with aphasia.

ABSTRACT: In this study, we examined regions in the left and right hemisphere language network that were altered in terms of the underlying neural activation and effective connectivity subsequent to language rehabilitation. Eight persons with chronic post-stroke aphasia and eight normal controls participated in the current study. Patients received a 10 week semantic feature-based rehabilitation program to improve their skills. Therapy was provided on atypical examples of one trained category while two control categories were monitored; the categories were counterbalanced across patients. In each fMRI session, two experimental tasks were conducted: (a) picture naming and (b) semantic feature verification of trained and untrained categories. Analysis of treatment effect sizes revealed that all patient

SUBMITTER: Kiran S 

PROVIDER: S-EPMC4460429 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature