BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy.

ABSTRACT: Knowledge of the mechanisms by which a cell detects exogenous DNA is important for controlling pathogen infection, because most pathogens entail the presence of exogenous DNA in the cytosol, as well as for understanding the cell's response to artificially transfected DNA. The cellular response to pathogen invasion has been well studied. However, spatiotemporal information of the cellular response immediately after exogenous double-stranded DNA (dsDNA) appears in the cytosol is lacking, in part because of difficulties in monitoring when exogenous dsDNA enters the cytosol of the cell. We have recently developed a method to monitor endosome breakdown around exogenous materials using transfection reagent-coated polystyrene beads incorporated into living human cells as the objective for microsc

SUBMITTER: Kobayashi S 

PROVIDER: S-EPMC4460496 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature