Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain.

ABSTRACT: Long noncoding RNAs (lncRNAs) have been implicated in numerous cellular processes including brain development. However, the in vivo expression dynamics and molecular pathways regulated by these loci are not well understood. Here, we leveraged a cohort of 13 lncRNAnull mutant mouse models to investigate the spatiotemporal expression of lncRNAs in the developing and adult brain and the transcriptome alterations resulting from the loss of these lncRNA loci. We show that several lncRNAs are differentially expressed both in time and space, with some presenting highly restricted expression in only selected brain regions. We further demonstrate altered regulation of genes for a large variety of cellular pathways and processes upon deletion of the lncRNA loci. Finally, we found that 4 of the 13 ln

SUBMITTER: Goff LA 

PROVIDER: S-EPMC4460505 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature