Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease.

ABSTRACT:

Background

The Pediatric Eosinophilic Esophagitis Symptom Score (PEESS v2.0) measures patient-relevant outcomes. However, whether patient-identified domains (dysphagia, gastroesophageal reflux disease [GERD], nausea/vomiting, and pain) align with clinical symptomology and histopathologic and molecular features of eosinophilic esophagitis (EoE) is unclear.

Objective

The purpose of this study was to determine whether clinical features of EoE, measured through PEESS v2.0, associate with histopathologic and molecular features of EoE. This represents a novel approach for analysis of allergic diseases, given the availability of allergic tissue biopsy specimens.

Methods

We systematically recruited treated and untreated pediatric patients with EoE (aged 2-18 years) and examin

SUBMITTER: Martin LJ 

PROVIDER: S-EPMC4460579 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature