Detection of gene annotations and protein-protein interaction associated disorders through transitive relationships between integrated annotations.

ABSTRACT:

Background

Increasingly high amounts of heterogeneous and valuable controlled biomolecular annotations are available, but far from exhaustive and scattered in many databases. Several annotation integration and prediction approaches have been proposed, but these issues are still unsolved. We previously created a Genomic and Proteomic Knowledge Base (GPKB) that efficiently integrates many distributed biomolecular annotation and interaction data of several organisms, including 32,956,102 gene annotations, 273,522,470 protein annotations and 277,095 protein-protein interactions (PPIs).

Results

By comprehensively leveraging transitive relationships defined by the numerous association data integrated in GPKB, we developed a software procedure that effectively detects and supplemen

SUBMITTER: Masseroli M 

PROVIDER: S-EPMC4460591 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature