Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption.

ABSTRACT:

Background

HFE, a major regulator of iron (Fe) homeostasis, has been suggested to be under positive selection in both European and Asian populations. While the genetic variant under selection in Europeans (a non-synonymous mutation, C282Y) has been relatively well-studied, the adaptive variant in Asians and its functional consequences are still unknown. Identifying the adaptive HFE variants in Asians will not only elucidate the evolutionary history and the genetic basis of population difference in Fe status, but also assist the future practice of genome-informed dietary recommendation.

Results

Using data from the International HapMap Project, we confirmed the signatures of positive selection on HFE in Asian populations and identified a candidate adaptive haplotype that is co

SUBMITTER: Ye K 

PROVIDER: S-EPMC4460683 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature