Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation.

ABSTRACT: During development, the rate of cell proliferation must be constantly monitored so that an individual tissue achieves its correct size. Mutations in genes that normally promote tissue growth often result in undersized, disorganized and non-functional organs. However, mutations in genes that encode growth inhibitors can trigger the onset of tumorigenesis and cancer. The developing eye of the fruit fly, Drosophila melanogaster, has become a premier model system for studies that are focused on identifying the molecular mechanisms that underpin growth control. Here, we examine the mechanism by which the Notch pathway, a major contributor to growth, promotes cell proliferation in the developing eye. Current models propose that the Notch pathway directly influences cell proliferation by regulati

SUBMITTER: Spratford CM 

PROVIDER: S-EPMC4460741 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature