MONSTER v1.1: a tool to extract and search for RNA non-branching structures.

ABSTRACT:

Background

Detection of RNA structure similarities is still one of the major computational problems in the discovery of RNA functions. A case in point is the study of the new appreciated long non-coding RNAs (lncRNAs), emerging as new players involved in many cellular processes and molecular interactions. Among several mechanisms of action, some lncRNAs show specific substructures that are likely to be instrumental for their functioning. For instance, it has been reported in literature that some lncRNAs have a guiding or scaffolding role by binding chromatin-modifying protein complexes. Thus, a functionally characterized lncRNA (reference) can be used to infer the function of others that are functionally unknown (target), based on shared structural motifs.

Methods

In our pre

SUBMITTER: Fiscon G 

PROVIDER: S-EPMC4460781 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature