GABA and glutamate levels in occlusal splint-wearing males with possible bruxism.

ABSTRACT:

Objective

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the pathophysiology of anxiety behavioural disorders such as panic disorder and post-traumatic stress disorder and is also implicated in the manifestation of tooth-grinding and clenching behaviours generally known as bruxism. In order to test whether the stress-related behaviours of tooth-grinding and clenching share similar underlying mechanisms involving GABA and other metabolites as do anxiety-related behavioural disorders, we performed a Magnetic Resonance Spectroscopy (MRS) study for accurate, in vivo metabolite quantification in anxiety-related brain regions.

Design

MRS was performed in the right hippocampus and right thalamus involved in the hypothalamic-pituitary-adrenal a

SUBMITTER: Dharmadhikari S 

PROVIDER: S-EPMC4460791 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature