Selective Functional Disconnection of the Dorsal Subregion of the Temporal Pole in Schizophrenia.

ABSTRACT: Although extensive resting-state functional connectivity (rsFC) changes have been reported in schizophrenia, rsFC changes in the temporal pole (TP) remain unknown. The TP contains several subregions with different connection patterns; however, it is not known whether TP subregions are differentially affected in schizophrenia. Sixty-six schizophrenia patients and 76 healthy comparison subjects underwent resting-state fMRI using a sensitivity-encoded spiral-in (SENSE-SPIRAL) imaging sequence to reduce susceptibility-induced signal loss and distortion. The TP was subdivided into the dorsal (TPd) and ventral (TPv) subregions. Mean fMRI time series were extracted for each TP subregion and entered into a seed-based rsFC analysis. Direct between-group comparisons revealed reduced rsFC between the

SUBMITTER: Xu L 

PROVIDER: S-EPMC4460906 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature