RCARE: RNA Sequence Comparison and Annotation for RNA Editing.

ABSTRACT: The post-transcriptional sequence modification of transcripts through RNA editing is an important mechanism for regulating protein function and is associated with human disease phenotypes. The identification of RNA editing or RNA-DNA difference (RDD) sites is a fundamental step in the study of RNA editing. However, a substantial number of false-positive RDD sites have been identified recently. A major challenge in identifying RDD sites is to distinguish between the true RNA editing sites and the false positives. Furthermore, determining the location of condition-specific RDD sites and elucidating their functional roles will help toward understanding various biological phenomena that are mediated by RNA editing. The present study developed RNA-sequence comparison and annotation for RNA edit

SUBMITTER: Lee SY 

PROVIDER: S-EPMC4460956 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature