Progression or resolution of coxsackievirus B4-induced pancreatitis: a genomic analysis.

ABSTRACT: Group B coxsackieviruses are associated with chronic inflammatory diseases of the pancreas, heart, and central nervous system. Chronic pancreatitis, which can develop from acute pancreatitis, is considered a premalignant disorder because it is a major risk factor for pancreatic cancer. To explore the genetic events underlying the progression of acute to chronic disease, a comparative analysis of global gene expression during coxsackievirus B4-induced acute and chronic pancreatitis was undertaken. A key feature of acute pancreatitis that resolved was tissue regeneration, which was accompanied by increased expression of genes involved in cell growth, inhibition of apoptosis, and embryogenesis and by increased division of acinar cells. Acute pancreatitis that progressed to chronic pancreatiti

SUBMITTER: Ostrowski SE 

PROVIDER: S-EPMC446102 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature