Compartmentalization of human immunodeficiency virus type 1 between blood monocytes and CD4+ T cells during infection.

ABSTRACT: Distinct sequences of human immunodeficiency virus type 1 (HIV-1) have been found between different tissue compartments or subcompartments within a given tissue. Whether such compartmentalization of HIV-1 occurs between different cell populations is still unknown. Here we address this issue by comparing HIV-1 sequences in the second constant region through the fifth hypervariable region (C2 to V5) of the surface envelope glycoprotein (Env) between viruses in purified blood CD14(+) monocytes and CD4(+) T cells obtained longitudinally from five infected patients over a time period ranging from 117 to 3,409 days postseroconversion. Viral populations in both cell types at early infection time points appeared relatively homogeneous. However, later in infections, all five patients showed heterog

SUBMITTER: Fulcher JA 

PROVIDER: S-EPMC446117 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature